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Powerful and Health

A cannabinoid receptor antagonist, also known simply as a cannabinoid antagonist or as an anticannabinoid, is a type of cannabinoidergic drug that binds to cannabinoid receptors (CBR) and prevents their activation by endocannabinoids. They include antagonists, inverse agonists, and antibodies of CBRs. The discovery of the endocannabinoid system led to the development of CB1 receptor antagonists. The first CBR antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of CBR antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/CB2 receptor antagonist.

Cannabis Sativa

Cannabis sativa is an annual herbaceous plant in the Cannabis genus, a species of the Cannabaceae family. People have cultivated Cannabis sativa throughout recorded history as a source of industrial fibre, seed oil, food, recreation, religious and spiritual moods, and medicine. Each part of the plant is harvested differently, depending on the purpose of its use

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CB2 Receptor

CB2 Receptor Information

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CB1 Receptor Information

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